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ZO Facial Refining 30ml

ZO Peptide Facial Refining Concentrate - now available in clinic

Product Overview

Peptide Facial Refining is ZO Skin Health’s anti-ageing serum in 2025, to complement the of and dermal fillers while also as a powerful treatment. This concentrated formula targets signs of ageing four peptide technologies, proven to deliver a more sculpted appearance and facial in just 12 weeks.​​

Key Benefits

Targets Wrinkles and Volume Loss: The formula addresses both visible lines (dynamic wrinkles) and static wrinkles whilst the appearance of lost volume, a visibly lifted and more refined .​

Complements Injectable Treatments: Designed to work synergistically with (like Botox) and dermal fillers, patients maintain between clinic visits whilst delivering improvements on its own.​

Supports Skin Structure: The Refining Complex the of skin’s structural integrity, promoting more facial geometry. The supports the skin’s production of acid for a plumper, fuller look.​

Reduces Visible Redness: The exclusive ZPOLY™ Complex helps to alleviate and fortify the skin’s protective .​

Clinical Results

In a 12-week clinical study involving 49 aged with Fitzpatrick skin types I-VI:

92% saw a in the of fine lines

84% reported visibly younger-looking facial geometry (a more sculpted, balanced face overall)

86% saw in facial hollow areas (places that had lost fullness)

82%  reduced wrinkles

96% said their skin felt smoother​

measurements showed:​

10%  in wrinkle volume after 4 weeks

11% improvement in skin after 12 weeks

8% improvement in skin firmness and elasticity after 2 weeks

12% improvement in elasticity by week 12

100% of subjects showed improvement in skin hydration by week 4

Advanced Peptide Technologies

The formula is by four cutting-edge technologies:​

1. Acetyl Octapeptide-3

Contains 8 amino acids

Targets the appearance of lines and wrinkles, especially around the and eye area

Functions as a to wrinkle formation​

2. Acetyl Hexapeptide-8

Contains 6 amino acids

Works synergistically with Acetyl Octapeptide-3

Provides greater in the appearance of deeper dynamic and static wrinkles​

3. Refining Peptide Complex

Blend of 2 active peptides: Palmitoyl Dipeptide-5 Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

a visibly more refined facial geometry

Improves the of skin’s integrity​

4. Volumizing Tripeptide ( Aminobutyroylvalylaminobutyric Urea Trifluoroacetate)

A unique tri-peptide

Supports the skin’s natural production of OnabotulinumtoxinAAbobotulinumtoxinAIncobotulinumtoxinAPrabotulinumtoxinALetibotulinumtoxinARimabotulinumtoxinBHyaluronic Acid FillersCalcium Hydroxylapatite FillersPoly-L-lactic Acid FillersPolymethylmethacrylate FillersAutologous Fat GraftingForehead Lines TreatmentGlabellar Frown Lines TreatmentCrow's Feet TreatmentBunny Lines TreatmentChemical Brow LiftLip FlipGummy Smile CorrectionMasseter ReductionJaw SlimmingDimpled Chin SmoothingCobblestone Chin SmoothingNefertiti Neck LiftMicro-BotoxMesotoxHyperhidrosis TreatmentChronic Migraine ReliefBruxism TreatmentTMJ TreatmentCervical Dystonia TreatmentNeck Spasm TreatmentBlepharospasm TreatmentLip AugmentationLip ContouringCheekbone EnhancementTear Trough FillersNasolabial Fold SofteningMarionette Line FillersLiquid RhinoplastyNon-Surgical Nose JobJawline ContouringJawline DefinitionChin AugmentationTemple VolumisingHand RejuvenationAcne Scar Subcision Filling for fuller, plumper-looking skin

Helps the appearance of lost volume​

ZPOLY™ Complex

This ZO-exclusive, plant-derived is a blend of four polysaccharide extracts:​

digitata (brown seaweed) extract

ficus-indica ( pear) stem cell extract

Schizophyllan (mushroom)

Galactoarabinan (larch tree)

Benefits: Helps prevent premature signs of ageing, skin restoration, boosts after a single application, and minimises the visible appearance of redness and for a calm skin tone.​

Full Ingredient List

Aqua/Water/Eau, Cyclopentasiloxane, Dipropylene Glycol, Glycol, Dimethicone, Glycerin, Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone/Vinyl Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Phospholipids, Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Cell Culture, Root Extract, Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Filtrate, Acetyl Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Fragrance (Parfum), Tocopherol, Beta-Glucan, Triphosphate, Vegetable Protein, Sodium Chloride, Gum, Phenoxyethanol.​

Formulation Properties

Alcohol-free and fragrance-free (though some list "Fragrance (Parfum)" in the full ingredient list)​

Silicone-based serum with a lightweight, smooth texture

for all skin types

Makes it a to procedures​

How to Use

Application: Apply 1-2 pumps to clean, dry skin​

Frequency: and/or .​

Placement: Apply before for maximum results. As a treatment serum, it should be after cleansing and toning but before heavier creams or SPF​

Pairing: Can be further with Firming Serum and AOX Serum for enhanced anti-ageing results​

Ideal Candidates

This serum is particularly beneficial for those who:​

Are both dynamic lines (from facial movement) and static lines ( visible when the face is relaxed)

Have signs of lost volume (around cheeks, under the eyes, or facial hollows) and want without to fillers

Would like to maintain or results from treatments like or Botox

Want to improve skin texture, firmness, and contour over time

Are a with backing

Before and afters

Results may vary from person to person, based on different personalised Skin plans.

Thames Skin Clinic News

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Thames Skin Clinic
Baylis Mews,

Twickenham TW1 3HQ

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